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Triamcinolone Acetonide

Clinical trials are studying Triamcinolone Acetonide in several patient groups, including people with fibromyalgia, frozen shoulder, rheumatoid arthritis, sudden hearing loss, and skin or eye conditions. These studies aim to see how well it works, how safe it is, and which treatment approach gives the best results.

Table of contents

Overview of the trials

Clinical trials with Triamcinolone Acetonide are testing it in different patient groups and for different medical problems, especially pain, joint disorders, ear conditions, and some skin and eye diseases.[1]

Most of the studies in the source data are Phase 3 trials, which usually compare treatments in larger groups of patients.[1] One study is Phase 2, and one is a low-intervention study in children with esophageal stricture after repair of esophageal atresia.[3]

Several trials are authorised, one is completed, and one is withdrawn.[1]

Conditions being studied

The trials cover a wide range of conditions. These include trapezius myofascial syndrome in fibromyalgia, frozen shoulder, rheumatoid arthritis, sudden sensorineural hearing loss, chronic shoulder pain, post-surgical scar pain, carpal tunnel syndrome, hidradenitis suppurativa, and osteoarthritis of the first carpometacarpal joint.[1]

Other studies include idiopathic inflammatory myopathies, geographic atrophy, strictures after esophageal atresia repair, and X-linked retinitis pigmentosa caused by RPGR mutations.[1][2]

This means the research is not limited to one disease area. Instead, Triamcinolone Acetonide is being studied as part of different treatment strategies in several specialties, including rheumatology, ear, orthopedics, dermatology, and ophthalmology.[1]

Study designs and phases

Most of the studies are interventional, meaning researchers assign a treatment and then compare outcomes.[1]

The trials are mostly in Phase 3, including studies in fibromyalgia-related trapezius pain, rheumatoid arthritis, frozen shoulder, carpal tunnel syndrome, hidradenitis suppurativa, chronic shoulder pain, post-surgical scar pain, and osteoarthritis of the thumb base joint.[1]

The Phase 2 studies include sudden sensorineural hearing loss and geographic atrophy, and the withdrawn Phase 3 study focused on X-linked retinitis pigmentosa.[1]

Some trials compare Triamcinolone Acetonide with saline, placebo, physiotherapy, or other active treatments, while others use it as one option in a broader treatment plan.[1]

Who can participate

Eligibility depends on the condition being studied. Some trials include adults only, such as studies in rheumatoid arthritis, chronic shoulder pain, carpal tunnel syndrome, hidradenitis suppurativa, and idiopathic inflammatory myopathies.[1]

Other trials include children and teenagers, such as the study in atopic dermatitis and the study in strictures after esophageal atresia repair.[1]

Some studies require a very specific diagnosis, such as persistent sudden sensorineural hearing loss after unsuccessful conservative therapy, or unilateral Menière’s disease in a one-year follow-up study of vertigo control.[1]

In general, the trial data show that participation is limited to people who match the exact diagnosis, age group, and study setting chosen by the researchers.[1]

What the trials measure

The main study results are different from one trial to another. Pain studies often use a Numeric Rating Scale or Visual Analogue Scale, which are simple tools for rating pain severity.[1]

Shoulder studies use the Shoulder Pain and Disability Index, which measures both pain and how much the problem limits daily activities.[1]

The rheumatoid arthritis studies measure remission or disease activity, including remission defined by DAS28-CRP and changes in disease activity over time.[1]

The hearing-loss study measures change in hearing threshold on day 30, while the Menière’s disease study measures control of vertigo attacks.[1]

Some studies also measure safety outcomes, such as adverse events, laboratory tests, electrocardiogram findings, eye examinations, and changes in eye pressure.[1][2]

Key trials using Triamcinolone Acetonide

The fibromyalgia trial studies local treatment of trapezius muscle pain and compares bupivacaine/triamcinolone with physiological saline and placebo. The main outcome is pain on the Visual Analogue Scale at weeks 2, 4, and 12.[1]

The sudden hearing loss trial uses intracochlear Triamcinolone Acetonide in patients with persistent sudden sensorineural hearing loss after unsuccessful conservative therapy. The main outcome is the mean change in hearing threshold at day 30 in the frequencies most affected by the hearing loss.[1]

The rheumatoid arthritis bridging trial compares corticosteroid bridging with Kenacort-A 40 against a JAK inhibitor strategy. The main outcome is the percentage of patients in remission at three months, using DAS28-CRP.[1]

The frozen shoulder study compares physical therapy, corticosteroid injections, and their combination to see which approach improves pain and function at 3 months. The main outcome is the Shoulder Pain and Disability Index.[1]

The carpal tunnel syndrome study tests an initial ultrasound-guided injection strategy against surgery as the main treatment. Success is defined by a Boston Carpal Tunnel Questionnaire symptom score of 1.5 or less after one year.[1]

The hidradenitis suppurativa trials use intralesional Triamcinolone Acetonide as part of comparison arms. Their main outcome is HiSCR50 at Week 16, which means at least a 50% drop in abscess and inflammatory nodule count without worsening of draining tunnels or fistulas.[1]

The thumb base osteoarthritis study checks whether intra-articular corticosteroid injections are better than saline after 4 weeks and compares three strategies at 12 weeks. It measures pain during activities using a Numeric Rating Scale.[1]

The esophageal atresia trial in children studies intralesional steroid injections to see whether they can prevent hard-to-treat strictures and reduce the number of dilatations needed over six months.[3]

The idiopathic inflammatory myopathy studies include Triamcinolone Acetonide among many background treatments, and one study focuses on long-term safety outcomes such as adverse events, laboratory results, lung function measures, and suicide-risk screening.[2]

What these studies mean for patients

For patients, these trials show that Triamcinolone Acetonide is being explored in many different ways, not just for one disease.[1]

Some studies ask whether it can reduce pain, improve movement, restore hearing, or help control inflammation better than another treatment.[1]

Other studies are mainly safety studies, especially when the medicine is used in a special way, such as inside the ear, under the skin, or near a nerve.[1]

Because the trials use different diseases, ages, and treatment plans, the results will not apply to every patient in the same way.[1]

Trial ID Phase Condition studied Status Enrollment
2024-520345-23-00 Phase 3 Trapezius myofascial syndrome in fibromyalgia patients Authorised 69
2024-513145-36-00 Phase 2 Sudden sensorineural hearing loss Authorised 40
2024-517112-30-00 Phase 3 Rheumatoid arthritis Authorised 168
2024-519728-26-00 Phase 3 Frozen shoulder Authorised 180
2024-518954-18-01 Phase 3 Post-surgical scar pain Authorised 60
2024-519892-24-00 Phase 3 Chronic shoulder pain Authorised 76
NCT06799000 Phase 3 Hidradenitis suppurativa Authorised 487
2024-513266-19-00 Phase 3 Hidradenitis suppurativa Authorised 532
2022-500746-16-00 Phase 2 Geographic atrophy Completed 285
2023-504905-36-00 Low Intervention Strictures after esophageal atresia repair Authorised 110
2023-505254-17-00 Phase 3 Osteoarthritis in first carpometacarpal joint Authorised 354
NCT04850118 Phase 3 X-linked retinitis pigmentosa Withdrawn 65
NCT05306548 Phase 3 Carpal tunnel syndrome Authorised 258
2024-511530-12-01 Phase 3 Rheumatoid arthritis according to 2010 criteria Authorised 300
NCT05895786 Phase 3 Active idiopathic inflammatory myopathies Authorised 318

FAQ

  • What kinds of conditions are being studied with Triamcinolone Acetonide? The trials include pain conditions, joint problems, ear disease, skin disease, and some eye-related studies. Examples are fibromyalgia with trapezius muscle pain, frozen shoulder, rheumatoid arthritis, sudden sensorineural hearing loss, hidradenitis suppurativa, and carpal tunnel syndrome.
  • Who can take part in these trials? Each trial has its own target group. Some studies include adults, while others include children or teenagers, and most require a specific diagnosis such as frozen shoulder, rheumatoid arthritis, or sudden hearing loss.
  • What phases are these Triamcinolone Acetonide trials in? Most of the studies are Phase 3 trials, which usually compare treatments in larger groups of patients. There is also a Phase 2 study in sudden hearing loss and one low-intervention study in children with esophageal stricture.
  • What are the trials trying to measure? The studies measure things such as pain scores, shoulder function, hearing change, remission in rheumatoid arthritis, and the number of procedures needed over time. Some trials also measure safety and treatment-related changes in tests or eye pressure.
  • Is Triamcinolone Acetonide always being tested alone? No. In some trials it is compared with saline, placebo, physiotherapy, or other treatments. In other studies it is part of a broader treatment strategy or used as one option among several corticosteroids.

Sperimentazioni cliniche in corso su Triamcinolone Acetonide

  • Studio comparativo tra diclofenac e desametasone in gocce oculari per il recupero post-operatorio dopo vitrectomia in pazienti con patologie maculari

    In arruolamento

    1 1 1 1
    Farmaci in studio:
    Belgio

  • Studio sull’Efficacia della Fisioterapia e delle Iniezioni di Triamcinolone Acetonide per il Trattamento della Spalla Congelata nei Pazienti Affetti da Questa Condizione

    In arruolamento

    1 1 1 1
    Malattie in studio:
    Farmaci in studio:
    Norvegia

  • Studio sull’uso di Dazukibart per la sicurezza a lungo termine nei pazienti con miopatie infiammatorie idiopatiche, inclusi dermatomiosite o polimiosite.

    In arruolamento

    1 1 1 1
    Farmaci in studio:
    Bulgaria Ungheria Italia Polonia Spagna Svezia

  • Studio sull’Efficacia del Triamcinolone Acetonide e della Radiofrequenza Pulsata nel Dolore Cronico alla Spalla

    In arruolamento

    1 1 1 1
    Malattie in studio:
    Farmaci in studio:
    Spagna

  • Studio sull’uso di Triamcinolone acetonide per la perdita improvvisa dell’udito neurosensoriale in pazienti con terapia conservativa non riuscita

    In arruolamento

    1 1 1
    Malattie in studio:
    Farmaci in studio:
    Austria

  • Studio di Estensione a Lungo Termine per Pazienti con Atrofia Geografica Secondaria a Degenerazione Maculare Legata all’Età con JNJ-81201887

    In arruolamento

    1 1
    Farmaci in studio:
    Belgio Cechia Danimarca Germania Ungheria Italia +5

  • Studio sull’Osteoartrite del Primo Articolazione Carpometacarpale: Triamcinolone Acetonide, Cloruro di Sodio o Terapia Occupazionale per Pazienti con Dolore Infiammatorio

    In arruolamento

    1 1 1
    Malattie in studio:
    Farmaci in studio:
    Norvegia

  • Studio sull’efficacia di Dazukibart in pazienti adulti con miositi infiammatorie idiopatiche attive (dermatomiosite o polimiosite)

    In arruolamento

    1 1 1 1
    Malattie in studio:
    Farmaci in studio:
    Belgio Bulgaria Francia Germania Ungheria Italia +4

  • Studio sull’uso di Triamcinolone Acetonide per prevenire le stenosi refrattarie nei bambini con atresia esofagea

    In arruolamento

    1 1 1 1
    Malattie in studio:
    Farmaci in studio:
    Danimarca Finlandia Francia Paesi Bassi Svezia

  • Studio sull’uso di metilprednisolone intratimpanico per ridurre gli attacchi di vertigine nella malattia di Menière

    In arruolamento

    1 1 1
    Malattie in studio:
    Farmaci in studio:
    Paesi Bassi

Glossario

  • Clinical trial: A research study in people that checks whether a treatment works, how safe it is, and how it compares with other options.
  • Phase 2: An earlier trial phase that often looks at whether a treatment may work and starts to collect more safety data.
  • Phase 3: A later trial phase with larger patient groups, usually comparing treatments and measuring real clinical benefit.
  • Interventional study: A study where researchers assign a treatment or procedure to see its effect.
  • Randomized: Patients are placed into treatment groups by chance, which helps make the comparison fair.
  • Placebo: A look-alike treatment with no active medicine, used to compare results.
  • Primary outcome: The main result the study is designed to measure, such as pain score, hearing change, or remission rate.
  • VAS: Visual Analogue Scale, a simple line or score used to measure pain intensity.
  • SPADI: Shoulder Pain and Disability Index, a questionnaire that measures shoulder pain and how much it limits daily life.
  • DAS28-CRP: A score used in rheumatoid arthritis to show how active the disease is and whether it is in remission.
  • HiSCR50: A response measure in hidradenitis suppurativa meaning at least a 50% drop in abscess and inflammatory nodule count, without worsening of draining tunnels or fistulas.
  • Intralesional injection: An injection given directly into the affected area or lesion.

Riferimenti

  1. https://clinicaltrials.gov/study/2024-520345-23-00
  2. https://studi-clinici.it/studio/studio-sullefficacia-di-dazukibart-in-pazienti-adulti-con-miositi-infiammatorie-idiopatiche-attive-dermatomiosite-o-polimiosite/
  3. https://clinicaltrials.gov/study/2023-504905-36-00